Mitochondrial Myopathy

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Mitochondrial myopathy are types of myopathy associated with mitochondrial disease.

Examples include:

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like syndrome (MELAS) varying degrees of cognitive impairment and dementia lactic acidosis strokes transient ischemic attacks hearing loss dysmotility weight loss

Myoclonic epilepsy and ragged-red fibers (MERRF) progressive myoclonic epilepsy clumps of diseased mitochondria accumulate in the subsarcolemmal region of the muscle fiber and appear as "ragged-red fibers" when muscle is stained with modified Gomori trichrome stain short stature

Kearns-Sayre syndrome (KSS) external ophthalmoplegia cardiac conduction defects sensory-neural hearing loss Progressive external ophthalmoplegia (PEO) progressive ophthalmoparesis is the cardinal feature symptomatic overlap with many other mitochondrial myopathies